The US geopolitical strategy developed from continental to global in the twentieth century, and the United States invested all its resources to achieve global hegemony and domination. However, the events of September 11, 2001, created an exceptional circumstance coinciding with the proliferation of weapons of mass destruction and extremist groups that practice violence and terrorism. The Middle East, which is adjacent to the Perssian Gulf, where American interests are a guarantee of American national security. According to the US geostrategic vision, Iran's nuclear and missile program and the Iranian government's external practices pose a direct threat to its interests. The decision to withdraw from the nuclear deal was the reason why the American ambition was to prevent Iran from obtaining nuclear weapons, and its external behavior would become a factor in the stability of the region. As the United States seeks to form the regional system in the world in accordance with the Geo-strategic concept in the twenty-first century, to achieve the conditions of global security stability and to secure its vital interests by imposing its cultural, economic and political model in the regions of the world and the Iranian nuclear file as a threat to its objectives in The Gulf region, as a factor disrupting the strategic balance of regional powers in the region, and a factor of concern for international peace and security.